发明名称 |
Chiral control |
摘要 |
The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonulcleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions. |
申请公布号 |
AU2013289880(A1) |
申请公布日期 |
2015.02.05 |
申请号 |
AU20130289880 |
申请日期 |
2013.07.12 |
申请人 |
WAVE LIFE SCIENCES PTE. LTD. |
发明人 |
BUTLER, DAVID;IWAMOTO, NAOKI;MEENA, MEENA;SVRZIKAPA, NENAD;VERDINE, GREGORY L.;ZLATEV, IVAN |
分类号 |
A61K31/7125;A61K38/17;A61K48/00 |
主分类号 |
A61K31/7125 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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