PYRAZINE COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE

摘要

PROBLEM TO BE SOLVED: To provide compounds useful as inhibitors of ATR protein kinase involved in cellular responses to DNA damage.SOLUTION: There is provided a pyrazine compound represented by formula IA or a pharmaceutically acceptable salt thereof. (Ring A is a 5 membered heteroaryl ring such as oxadiazol or thiadiazolyl; Y is a C-aliphatic chain, where up to three methylene units of the aliphatic chain are optionally replaced with O, S, NR, C(O) or S(O); J is H or C-alkyl; Q is a 5-6 membered monocyclic aromatic ring containing 0-4 heteroatoms selected from N, O and S; Ris a 3-7 membered monocyclic, saturated ring, partially unsaturated ring or aromatic ring containing 0-4 heteroatoms selected from N, O or S.