| 发明名称 |
BISPECIFIC CHIMERIC ANTIGEN RECEPTORS AND THERAPEUTIC USES THEREOF |
| 摘要 |
The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors. |
| 申请公布号 |
US2015038684(A1) |
申请公布日期 |
2015.02.05 |
| 申请号 |
US201314376610 |
申请日期 |
2013.02.13 |
| 申请人 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
发明人 |
Jensen Michael |
| 分类号 |
C07K16/46;A61K47/48;A61K38/17;C07K16/28 |
主分类号 |
C07K16/46 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A bispecific chimeric antigen receptor, comprising:
a. at least two antigen-specific targeting regions; b. an extracellular spacer domain; c. a transmembrane domain; d. at least one co-stimulatory domain; and e. an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. |
| 地址 |
Seattle WA US |
