Modular Imaging Agents Containing Amino Acids and Peptides

摘要

Targeting agents are derived from coupling together formed imaging amino acids or formed multi-modal, multi-chelating metal, multi-dye imaging agents, or combinations of these, that may be conjugated directly, or activated, or attached to linkers to which targeting groups, such as peptides, proteins, antibodies, aptamers, or small molecule inhibitors, may be conjugated in the final steps of the synthesis to form a wide variety of TMIAs.

主权项

1. A process for synthesizing a targeted imaging agent comprising:
providing a) an amino acid imaging agent comprising a protected or free acid and a protected or free amine or b) multiple amino acid imaging agents in a peptide chain comprising a protected or free acid and a protected or free amine; and coupling the a) amino acid imaging agent or b) multiple amino acid imaging agents in a peptide chain to a targeting agent comprising a free amine, sulfur, or free acid, in a manner to provide a targeted imaging agent.