Sustained Release Formulation Comprising Octreotide and Two or More Polyactide-co-glycolide Polymers

摘要

The present invention relates to sustained release formulations comprising as active ingredient octreotide or a pharmaceutically-acceptable salt thereof and two or more different polylactide-co-glycolide polymers (PLGAs).

主权项

1. A sustained release pharmaceutical composition in the form of microparticles comprising as active ingredient octreotide as a pamoate salt thereof at a loading of from 15% to 20% and a biocompatable polymer matrix which is a blend of two or more polylactide-co-glycolide polymers (PLGAs) each having a different lactide:glycolide ratio in the range from 85:15 to 65:35, wherein the inherent viscosity of the PLGAs is between 0.4-0.6 dl/g in chloroform and the release of the active ingredient is three or more months.