| 主权项 |
1. A percutaneously or transvenously delivered catheter system configured to stimulate a phrenic nerve and diaphragm in conjunction with a patient's own breathing, comprising:
a mechanical ventilator configured to provide ventilation to the patient; at least one electrode extending from the catheter and in electrical communication with the phrenic nerve or diaphragm of the patient; a control unit in electrical communication with the at least one electrode and whereby the control unit receives sensed respiration activity, wherein the control unit is programmed to identify the intrinsic breathing cycle of the patient and create an intrinsic baseline profile thereof: wherein the control unit is further programmed to generate an electrical stimulation signal in response to the sensed respiration and deliver the electrical stimulation signal through the at least one electrode to the diaphragm or phrenic nerve tissue, wherein said control unit is programmed to deliver an electrical stimulation signal comprising a burst or series of pulses during inspiration to adjust the breathing cycle of said patient, wherein the control unit is further programmed to monitor the adjusted breathing cycle of the patient, compare it against the patient's baseline intrinsic level and when the breathing is not at a desired level, to then adjust one or more parameters of the electrical stimulation signal and provide stimulation with each breath to incrementally adjust until the breathing cycle is further adjusted to reach the desired level, and wherein the electrical stimulation signal is configured to elicit a diaphragm response by stimulating to increase a tidal volume by supplementing an existing breath. |
