PROCESS FOR THE PREPARATION OF OXYMORPHONE

摘要

The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation iscarried out at one or more temperatures greater than 40°C in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6α-oxymorphol produced is ≤ 3.00area % as determined by HPLC.