| 摘要 |
Provided is a treatment or preventive drug for diseases, disorders or conditions relating to abnormalities in the extracellular matrix (ECM) of the corneal endothelium, said drug containing a TGF ß-signal inhibitor. More specifically, said diseases, disorders and conditions refer to those relating to Fuchs' corneal endothelial dystrophy. Such disorders include photophobia, blurred vision, vision disorders, eye pain, tearing, hyperaemia, pain, bullous keratopathy, eye discomfort, contrast reduction, glare, edema of the corneal stroma, bullous keratopathy and corneal opacity. One optimal TGF ß-signal inhibitor is 4-[4-(1,3-benzodioxole-5-yl)-5-(2-pyridinyl)-1H-imidazole-2-yl]benzamide. |
