| 发明名称 |
PROCESS |
| 摘要 |
The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6α-oxymorphol produced is ≦3.00 area % as determined by HPLC. |
| 申请公布号 |
US2015038715(A1) |
申请公布日期 |
2015.02.05 |
| 申请号 |
US201414173314 |
申请日期 |
2014.02.05 |
| 申请人 |
JOHNSON MATTHEY PUBLIC LIMITED COMPANY |
发明人 |
GRANT EWART;HEINRICH BRIAN;MATHARU SAROOP;ARCHER NICOLAS |
| 分类号 |
C07D489/02 |
主分类号 |
C07D489/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxymorphone acid adduct comprises 6α-oxymorphol in an amount ≦3.00 area % as determined by HPLC. |
| 地址 |
LONDON GB |
