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1. A compound having structural Formula (I):or a pharmaceutically acceptable salt or solvate thereof;
wherein: R2, R3, R4, and R6 are independently hydrogen or a moiety selected from structural formula (a), (b), (c), (d), (e), (f), and (g): R1 is a moiety selected from structural formula (a), (b), (c), (f), and (g); or a nucleoside phosphate moiety; X is oxygen or sulfur; L1 and L2 are each independently a covalent bond, —O—, or —NR10a—; R10a is hydrogen or optionally substituted alkyl; R1a and R2a are each independently hydrogen, optionally substituted alkyl, optionally substituted heteroalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, —Xa—C(O)—O—R11a, or —Xa—O—C(O)—O—R11a; Xa is optionally substituted alkylene; each R11a is independently hydrogen, optionally substituted alkyl, or optionally substituted heteroalkyl; R3a is optionally substituted alkyl; or alternatively, R3a, together with the carboxyl moiety to which it is attached, form a monopeptidyl or dipeptidyl group; each R8a and R9a is independently hydrogen or optionally substituted alkyl; m is 1 or 2; Z is hydrogen, lower alkyl, an amide group, a lactam group, an ester group, a lactone group, an urea group, a cyclic urea group, a carbonate group, a cyclic carbonate group, a carbamate group, a cyclic carbamate group, or a moiety selected from (a), (b), (c), and (f); R5 is hydrogen, G+, optionally substituted alkyl, or a moiety selected from (a), (b), (c), (f), and (g); and G+ is a charged organic amine moiety; or alternatively, OR3 and OR6 are taken together to form a lactone structure represented by Formula (Ia):and
with the following provisos: (a) at least one of R1, R2, R3, R4, R5, and R6 is not H; and (b) R3a is not optionally substituted alkyl unless (1) OR3 and OR6 are taken together to form a lactone structure of Formula (Ia), or (2) R5 is (f). |
