HANDHELD DIAGNOSTIC SYSTEM WITH CHIP-SCALE MICROSCOPE AND DISPOSABLE SAMPLE HOLDER HAVING BUILT-IN REFERENCE FEATURES

摘要

A handheld diagnostic system may include a disposable sample holder and an analysis module having a chip-scale microscope. The sample holder may have a transparent portion that may be inserted into the analysis module. The transparent portion may have test chambers for containing respective portions of a biological sample. The transparent portion may also include built-in reference features such as reference surfaces, reference markings, and/or reference structures. The chip-scale microscope may include an image sensor for capturing images of the sample and the reference features as the sample holder is inserted into the analysis module. Images of the reference features may be compared with images of the sample and may be used to determine the color, opacity, reflectivity, cell size, and/or cell concentration associated with the sample. The analysis module may transmit sample imaging data to a portable electronic device.

主权项

1. Apparatus, comprising:
a sample holder having reference features and configured to receive a biological sample; a handheld analysis module having a housing with an opening, wherein the opening is configured to receive the sample holder and wherein the analysis module comprises a chip-scale microscope having an image sensor for capturing images of the reference features and the biological sample in the sample holder as the sample holder is inserted into the opening; and storage and processing circuitry configured to analyze the images of the biological sample based on the images of the reference features.