| 发明名称 |
SODIUM SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE |
| 摘要 |
A preparation replete with crystals of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection. |
| 申请公布号 |
US2015038713(A1) |
申请公布日期 |
2015.02.05 |
| 申请号 |
US201414515673 |
申请日期 |
2014.10.16 |
| 申请人 |
Toyama Chemical Co., Ltd. |
发明人 |
TAKAKURA Keiko;Nakamatsu Namika;Takeshima Sakiko;Uehara Sayuri |
| 分类号 |
C07D241/24 |
主分类号 |
C07D241/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for producing a lyophilized preparation containing a crystal of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide, comprising the steps:
(1) cooling an aqueous solution containing a sodium salt of 6-fluoro-3-hydroxy-2-pyrazinecarboxamide to produce a frozen product; (2) increasing the temperature of the frozen product; (3) cooling the frozen product again; and (4) carrying out lyophilization. |
| 地址 |
Tokyo JP |
