主权项 |
1. A crystalline Cabazitaxel alkyl acetate solvate selected from:
a) Crystalline Cabazitaxel ethyl acetate solvate, designated as Form VII, characterized by data selected from one or more of the following: a powder X-ray diffraction pattern having peaks at 7.9, 8.6, 10.0, 10.2 and 15.8 degrees two theta±0.1 degrees two theta, and also having no peak in the area from 10.5 to 12.1 degrees two theta; by a powder X-ray diffraction pattern substantially as depicted in FIG. 1; and by combinations of these data; b) Crystalline isopropyl acetate solvate of cabazitaxel, designated as Form VIII, characterized by data selected from one or more of the following: a powder X-ray diffraction pattern having peaks at 7.9, 8.6, 10.0, 10.2 and 16.6 degrees two theta±0.1 degrees two theta, and also having no peak in the area from 10.5 to 12.1 degrees two theta; and by a powder X-ray diffraction pattern substantially as depicted in FIG. 4; and by a combination of these data; c) Crystalline Cabazitaxel methyl acetate solvate, designated as Form XVII, characterized by data selected from one or more of the following: a powder X-ray diffraction pattern having peaks at 8.0, 8.7, 14.2, 15.1 and 15.9 degrees two theta±0.1 degrees two theta; by a powder X-ray diffraction pattern substantially as depicted in FIG. 37, and by a combination of these data; d) Crystalline Cabazitaxel butyl acetate solvate, designated as Form XVIII, characterized by data selected from: a powder X-ray diffraction pattern having peaks at 8.6, 13.6, 14.0, 19.2 and 19.8 degrees two theta±0.1 degrees two theta; by a powder X-ray diffraction pattern substantially as depicted in FIG. 40, and by a combination of these data; and e) Crystalline Cabazitaxel isobutyl acetate, designated as Form XXI, characterized by data selected from one or more of the following: a powder X-ray diffraction pattern having peaks at 8.6, 14.0, 15.6, 16.3 and 19.6 degrees two theta±0.1 degrees two theta; by a powder X-ray diffraction pattern substantially as depicted in FIG. 49, and by a combination of these data. |