TYROSINE KINASE INHIBITORS

摘要

The present disclosure relates to the field of tyrosine kinase enzyme inhibition, in particular anaplastic lymphoma kinase (ALK) inhibition using novel small molecules. Provided are compounds capable to modulate ALK activity, compositions that comprise the compounds, and methods of using the compounds for the treatment or prevention of diseases or conditions that are characterized by ALK activity or expression.

主权项

1. A method of modulating a tyrosine kinase activity comprising the step of contacting the tyrosine kinase with an amount of a compound represented by the structure of formula (45)or its stereoisomer, tautomer, pharmaceutically acceptable salt, or any combination thereof, effective to modulate the tyrosine kinase activity.