Thiophene-carboxamides useful as inhibitors of protein kinases

摘要

The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

主权项

1. A compound of formula I:wherein
R1 is H; G is —O—; L is C0-3alkyl optionally substituted with 0-3 JL; Ring A isRing A is optionally substituted with 0-3 JA;
Ring B is phenyl optionally substituted with 0-5 JB; Ring B′ is a 5-8 membered aromatic or nonaromatic monocyclic ring containing 0-3 heteroatoms selected from O, N, and S; Ring B′ is optionally substituted with 0-4 JB′; each JA and JB is independently H, unsubstituted C1-6alkyl, halo, NO2, CN, OH, OR, SH, SR, NH2, NHR, N(R)2, COH, COR, CONH2, CONHR, CONR2, NHCOR, NRCOR, NHCONH2, NHCONHR, NHCON(R)2, SO2NH2, SO2NHR, SO2N(R)2, NHSO2R, or NRSO2R; each JL and JZ is independently H, halo, unsubstituted C1-6alkyl NO2, CN, —NH2, —OH, or —CO2H; and R is H.