METHODS FOR BIOSYNTHESIZING 3-OXOPENT-4-ENOYL-CoA

摘要

This document describes biochemical pathways that include the production of 3-oxopent-4-enoyl-CoA by condensation of acryloyl-CoA and acetyl-CoA using a &bgr;-ketothiolase with a SER-HIS-HIS catalytic triad. These pathways described herein rely on enzymes such as, inter alia, dehydrogenases, dehydratases and &bgr;-ketothiolases.