Modified L-nucleic Acid

摘要

A modified L-nucleic acid, containing an L-nucleic acid part conjugated to a non-L-nucleic acid part is described. The conjugate has extended retention time in and demonstrates a delayed elimination from an organism.

主权项

1. A modified L-nucleic acid, comprising a L-nucleic acid part and a non-L-nucleic acid part, wherein the L-nucleic acid part is conjugated with the non-L-nucleic acid part, and the conjugation of the L-nucleic acid part with the non-L-nucleic acid part leads to a retarded excretion from an organism compared to a L-nucleic acid comprising only the L-nucleic acid part, and wherein said L-nucleic acid part is a spiegelmer.