N-TERMINALLY MODIFIED OLIGOPEPTIDES AND USES THEREOF

摘要

The present invention is related to N-terminally fatty acid modified peptides or oligopeptides and pharmaceutical compositions comprising such.

主权项

1. An N-terminally acylated peptide or oligopeptide having the structure
Cx-Aaa10-Aaa9-Aaa8-Aaa7-Aaa6-Aaa5-Aaa4-Aaa3-Aaa2-Aaa1-OH (SEQ ID No: 1, Chem I) where Cx is a fatty acid with a length between 6 and 20 carbons, and wherein Aaa1 is an aromatic amino acid; Aaa2 is any amino acid except Lys or Asp; Aaa3 is any amino acid; Aaa4-10 is any amino acid or absent.