| 摘要 |
Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. |
| 申请人 |
AMGEN INC. |
发明人 |
XIONG, YUMEI;ZHANG, YI;SHENG, JACKIE ZEQI;HAMBURGER, AGNES EVA;VENIANT-ELLISON, MURIELLE;SHIMAMOTO, GRANT;MIN, XIAOSHAN;WANG, ZHULUN;TANG, JIE;KANNAN, GUNASEKARAN;MOCK, MARISSA;WALKER, KENNETH WILLIAM |
