发明名称 |
ARTIFICIAL NUCLEIC ACID MOLECULES |
摘要 |
The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3′UTR element comprising a nucleic acid sequence which is derived from the 3′UTR of an albumin gene or from a variant of the 3′UTR of an albumin gene. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination. Furthermore, the invention relates to the use of a 3′UTR element comprising a nucleic acid sequence which is derived from the 3′UTR of an albumin gene or from a variant of the 3′UTR of an albumin gene for the stabilization and/or prolongation of protein expression from a nucleic acid sequence comprising such 3′UTR element. |
申请公布号 |
EP2831239(A1) |
申请公布日期 |
2015.02.04 |
申请号 |
EP20130712694 |
申请日期 |
2013.03.27 |
申请人 |
CUREVAC GMBH |
发明人 |
THESS, ANDREAS;KALLEN, KARL-JOSEF |
分类号 |
C12N15/67;C12N15/85 |
主分类号 |
C12N15/67 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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