发明名称 |
PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS |
摘要 |
<p>Reagents are disclosed for chemoselective tagging of methionine residues in peptides and polypeptides, subsequent bioorthogonal tag functionalization, and cleavage of the tags when desired to regenerate unmodified samples. This method compliments other peptide tagging strategies and adds capability for tag removal, which may be useful for release of therapeutic peptides from a carrier, or release of tagged protein digests from solid supports.</p> |
申请公布号 |
EP2831090(A1) |
申请公布日期 |
2015.02.04 |
申请号 |
EP20130770096 |
申请日期 |
2013.03.26 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
DEMING, TIMOTHY J.;KRAMER, JESSICA R. |
分类号 |
C07K1/113;C07K1/02 |
主分类号 |
C07K1/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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