发明名称 |
ANTI THIRD PARTY CENTRAL MEMORY T CELLS, METHODS OF PRODUCING SAME AND USE OF SAME IN TRANSPLANTATION AND DISEASE TREATMENT. |
摘要 |
<p>A method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (PBMC) with a third party antigen or antigens in the presence of IL-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of IL- 21, IL-15 and IL-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory T-lymphocyte (Tcm) phenotype.</p> |
申请公布号 |
MX2014002771(A) |
申请公布日期 |
2015.02.04 |
申请号 |
MX20140002771 |
申请日期 |
2012.09.06 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
YAIR REISNER;YAKI EIDELSTEIN;ERAN OPHIR;ASSAF LASK;RAN AFIK;NOGA OR-GEVA;ESTHER BACHAR-LUSTIG |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|