发明名称 |
Chimeric viruses presenting non-native surface proteins and uses thereof |
摘要 |
The present invention provides chimeric negative-stand RNA viruses that allow a subject, e.g., an avian, to be immunized against two infectious agents by using a single chimeric virus of the invention. In particular, the present invention provides chimeric Newcastle Disease viruses (NDV) engineered to express and incorporate into their virions a fusion protein comprising the ectodomain of a protein of an infectious agent and the transmembrane and cytoplasmic domain of an NDV protein. Such chimeric viruses induce an immune response against NDV and the infectious agent. |
申请公布号 |
GB2447187(C) |
申请公布日期 |
2015.02.04 |
申请号 |
GB20080011526 |
申请日期 |
2006.12.01 |
申请人 |
MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY |
发明人 |
PETER PALESE;ADOLFO GARCIA-SASTRE |
分类号 |
A61K39/00;A61K39/145;A61K39/17;A61P31/14;A61P31/16;C07K14/11;C07K14/125 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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