发明名称 |
DR5 RECEPTOR AGONIST COMBINATIONS |
摘要 |
The present invention includes apoptotic compositions and methods for inducing apoptosis of cancer cells independent of NK cells. An apoptotic composition comprises a cooperative combination of antibodies that specifically bind to human DR5, or a cooperative combination of an anti-DR5 antibody and TRAIL. Administration of therapeutically effective amounts of an apoptotic composition induces apoptosis of apoptosis sensitive cancer cells. |
申请公布号 |
EP2831116(A1) |
申请公布日期 |
2015.02.04 |
申请号 |
EP20130715858 |
申请日期 |
2013.03.27 |
申请人 |
AMGEN INC. |
发明人 |
HOLLAND, PAMELA MARY;GRAVES, JONATHAN DAVID;KORDICH, JENNIFER JOY;PIASECKI, JULIA CATHERINE;FOLTZ, IAN NEVIN |
分类号 |
C07K16/28;C07K2/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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