| 摘要 |
A valve system in a fluidic cartridge comprises a fluid pathway for passing a liquid sample from an upstream end to a downstream end, a sample processing chamber, such as a PCR chamber 56a, 56b within the fluid pathway having an inlet valve 58a, 58b upstream of the sample processing chamber, and an outlet valve 60a, 60b downstream of the sample processing chamber. A downstream sample processing region, such as a detection chamber 62a-d is provided within the fluid pathway downstream of the outlet valve, and a bypass channel 66a, 66b is coupled to the fluid pathway at a junction between the outlet valve and the downstream sample processing region. The valve system is configured such that surplus liquid downstream of the outlet valve may be evacuated through the bypass channel when the outlet valve is closed, leaving a metered volume of liquid sample between the inlet valve and the downstream sample processing region. At least one compressible element, such as a gas spring 64a-d, may be provided downstream of the downstream sample processing region. |
