Neuromodulation cryotherapeutic devices and associated systems and methods

摘要

Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

主权项

1. A cryotherapeutic device, comprising:
an elongated shaft having a distal portion, the shaft being configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium; a supply lumen along at least a portion of the shaft, the supply lumen being configured to receive liquid refrigerant; and a cooling assembly at the distal portion, the cooling assembly having a delivery state and a deployed state, the cooling assembly including an orifice and an applicator including an elongated balloon having a length, a balloon proximal portion, a balloon middle portion, and a balloon distal portion along the length, the balloon being curved along the length such that the balloon has a first wall portion having a generally concave curvature along the length and a second wall portion having a generally non-concave curvature along the length in the deployed state, wherein the balloon middle portion is configured to contact the renal artery and/or renal ostium generally along the second wall portion and generally not along the first wall portion in the deployed state, the balloon has a heat-transfer portion in fluid communication with the orifice, wherein the second wall portion at the balloon middle portion at least partially defines the heat-transfer portion, and wherein the heat-transfer portion has a heat-transfer rate in the deployed state while the cooling assembly receives refrigerant sufficient to cause therapeutically-effective, cryogenic renal-nerve modulation.