Compositions comprising biomembrane sealing agent for treatment of neuronal injury, and methods of use

摘要

The invention provides compositions, kits, and methods for treatment of neuronal injury. In one embodiment, the composition comprises a biomembrane sealing agent, such as PEG, and a bioactive agent, such as a magnesium compound. The biomembrane sealing agent and/or the bioactive agent an intravenous administration, an intramuscular administration, an intrathecal administration, a subcutaneous administration, an epidural administration, a parenteral administration, a direct application onto or adjacent to a site of the pathological condition, and any combinations thereof. Alternatively, the biomembrane sealing agent and/or the bioactive agent may be delivered from a pump or an implant.

主权项

1. An intravenous pharmaceutical composition for treating a neuronal injury comprising a therapeutically effective amount of a biomembrane sealing agent comprising between 20 and 50% w/w of polyethylene glycol and at least one magnesium compound, wherein the polyethylene glycol comprises PEG 3350.