Silicone hydrogel lens with a crosslinked hydrophilic coating

摘要

The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

主权项

1. A readily-usable silicone hydrogel contact lens, comprising a silicone hydrogel material and a crosslinked hydrophilic coating thereon, wherein the crosslinked hydrophilic coating is attached onto the silicone hydrogel contact lens through neutral, hydroxyl-containing covalent linkages each of which is obtained by reacting, in a crosslinking reaction at a temperature from about 40° C. to about 140° C., one positively-charged azetidinium group with one functional group selected from the group consisting of amino groups, thiol groups and carboxylate ions, wherein the readily-usable silicone hydrogel contact lens has a surface hydrophilicity/wettability characterized by having an averaged water contact angle of about 90 degrees or less.