| 发明名称 | RAF gene fusions | ||
| 摘要 | The present disclosure relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present disclosure relates to RAF gene fusions as diagnostic markers and clinical targets for cancer. | ||
| 申请公布号 | US8945556(B2) | 申请公布日期 | 2015.02.03 |
| 申请号 | US201113300063 | 申请日期 | 2011.11.18 |
| 申请人 | The Regents of The University of Michigan | 发明人 | Chinnaiyan Arul;Palanisamy Nallasivam;Kalyana-Sundaram Shanker |
| 分类号 | A61K39/395;C12Q1/68 | 主分类号 | A61K39/395 |
| 代理机构 | Casimir Jones, S.C. | 代理人 | Isenbarger Thomas A.;Casimir Jones, S.C. |
| 主权项 | 1. A composition comprising at least one of the following: (a) an oligonucleotide probe that hybridizes to a junction of a chimeric genomic DNA or a chimeric mRNA, wherein a 5′ portion of the chimeric genomic DNA or the chimeric mRNA is from an AGTRAP gene and a 3′ portion of the chimeric genomic DNA or the chimeric mRNA is from a RAF family member gene; (b) an antibody specific for a fusion protein having an amino-terminal portion encoded by an angiotensin II, type I receptor-associated protein (AGTRAP) gene and a carboxy-terminal portion encoded by a kinase domain of a RAF family member gene. | ||
| 地址 | Ann Arbor MI US | ||