Processes for preparing a polymeric compound

摘要

The present invention provides methods for preparing a polymeric compound of Formula I:;
or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.

主权项

1. A method for preparing a compound of Formula I:or pharmaceutically acceptable salt thereof, comprising:
a) removing the Cbz groups from a compound of Formula II:or pharmaceutically acceptable salt thereof, under a hydrogen source chosen from H2 gas, formic acid, ammonium formate, and 1,4-cyclohexadiene, and a metal catalyst chosen from Pd/C, Pd black, Pd(OH)2, PdCl2, Raney Ni, a platinum catalyst, a rhodium catalyst, and a ruthenium catalyst to form the compound of Formula I, or pharmaceutically acceptable salt thereof; and
b) optionally isolating the compound of Formula I, or pharmaceutically acceptable salt thereof.