发明名称 |
Multi-targeting short interfering RNAs |
摘要 |
The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets. |
申请公布号 |
US8946401(B2) |
申请公布日期 |
2015.02.03 |
申请号 |
US201113287493 |
申请日期 |
2011.11.02 |
申请人 |
City of Hope |
发明人 |
Rossi John J.;Snove, Jr. Ola;Ehsani Ali;Saetrom Pal;Hoehn Britta;Zhang Jane;Aagaard Lars |
分类号 |
C07H21/04 |
主分类号 |
C07H21/04 |
代理机构 |
Rothwell, Figg, Ernst & Manbeck P.C. |
代理人 |
Rothwell, Figg, Ernst & Manbeck P.C. |
主权项 |
1. A multi-targeting RNA molecule that targets two or more different desired target sequences, wherein the RNA molecule comprises a first strand having a 5′ terminus and a 3′ terminus and a second strand having a 5′ terminus and a 3′ terminus, wherein the first strand is perfectly complementary to a desired mRNA target sequence, wherein the second strand contains two or more seed matches optimally spaced in a desired 3′ UTR containing target gene, wherein the first strand and second strand are not completely complementary and wherein the first strand and the second strand hybridize to form a double stranded RNA molecule, wherein the double stranded RNA molecule is a single duplex. |
地址 |
Duarte CA US |