Human protein tyrosine phosphatase inhibitors and methods of use

摘要

The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to compositions comprising said human protein tyrosine phosphatase beta (HPTP-β) inhibitors, and to methods for regulating angiogenesis.

主权项

1. A method for treating skeletal muscle and myocardial ischemia, stroke, coronary artery disease, and peripheral vascular disease comprising, contacting a subject with an effective amount of a compound having the formula: wherein R is a substituted or unsubstituted thiazolyl unit having the formula: R4 and R5 are each independently chosen from: i) hydrogen; ii) substituted or unsubstituted C1-C6 linear, C3-C6 branched, or C3-C6 cyclic alkyl; iii) substituted or unsubstituted phenyl; iv) substituted or unsubstituted heteroaryl; or R4 and R5 can be taken together to form a saturated or unsaturated ring having from 5 to 7 atoms; said substitutions are independently chosen from one or more C1-C6 linear, C3-C6 branched, or C3-C6 cyclic alkyl, halogen, hydroxyl, or cyano units; R6 is a unit chosen from: i) hydrogen; ii) substituted or unsubstituted C1-C6 linear, C3-C6 branched, or C3-C6 cyclic alkyl; iii) substituted or unsubstituted phenyl; and iv) substituted or unsubstituted heteroaryl; R1 is chosen from: i) hydrogen; ii) C1-C6 linear or C3-C6 branched alkyl; iii) substituted or unsubstituted phenyl; or iv) substituted or unsubstituted benzyl; R2 is chosen from: i) C1-C6 linear or C3-C6 branched alkyl; or ii) C1-C6 linear or C3-C6 branched alkoxy; R3 is hydrogen or C1-C4 linear or C3-C4 branched alkyl; or a pharmaceutically acceptable salt thereof.