Fused aminodihydrothiazine derivatives

摘要

A compound represented by the general formula:;
or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein Ring A is a C6-14 aryl group or the like, L is —NReCO— or the like (wherein Re is a hydrogen atom or the like), Ring B is a C6-14 aryl group or the like, X is a C1-3 alkylene group or the like, Y is a single bond or the like, Z is a C1-3 alkylene group or the like, R1 and R2 are each independently a hydrogen atom or the like, and R3, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.

主权项

1. A compound represented by the formula:or a pharmaceutically acceptable salt thereof, wherein:
R3 and R4 are independently selected from the group consisting of H and C1-6 alkyl, wherein the C1-6 alky is optionally substituted by 1, 2, or 3 substituents; R7a, R7b, and R7C are independently selected from the group consisting of H and X; R8a, R8b, and R8C are independently selected from the group consisting of H, X, CHmXn, and OCHmXn; wherein m is 0, 1, or 2; n is 1, 2, or 3; and X is halogen selected from the group consisting of fluorine, chlorine, bromine and iodine.