发明名称 Imidated biopolymer adhesive and hydrogel
摘要 Biologically compatible polymers carry an imide and can be used as an adhesive, a hydrogel or both. A second biologically compatible polymer reactive with the imidated polymer can be used therewith to seal openings.
申请公布号 US8946191(B2) 申请公布日期 2015.02.03
申请号 US200712517672 申请日期 2007.12.04
申请人 The Johns Hopkins University 发明人 Elisseeff Jennifer H.;Strehin Iossif A.
分类号 A61K31/737;C08F8/30;A61L24/00;A61L24/08;A61L27/20;A61L27/34;A61L27/52;A61L27/58;A61L31/04;A61L31/08;A61L31/14;C08B37/00;C08L5/08;C09J171/02;C08L71/02;C08G65/329;C08G65/333;C08B37/08 主分类号 A61K31/737
代理机构 Johns Hopkins Technology Transfer 代理人 Johns Hopkins Technology Transfer
主权项 1. A composition comprising a hydrophilic biologically compatible first polymer, wherein the first polymer is isolated and purified chondroitin sulfate functionalized with an imide group, and at least one second hydrophilic biologically compatible polymer, wherein said second polymer comprises at least one amine group and is capable of reacting with the first polymer, the second polymer being selected from the group consisting of poly(ethylene oxide), partially or fully hydrolyzed poly(vinyl alcohol), polypropylene oxide) block copolymers, poly(vinylpyrrolidone), poly(ethyloxazoline), poly(ethylene oxide)-co-poly(propylene oxide) block copolymers, poloxamines, carboxymethyl cellulose, hydroxyalkylated cellulose, polypeptides, polysaccharides, carbohydrates, polysucrose, dextran, heparin sulphate, keratan sulfate, heparin, alginate, gelatin, collagen, albumin, ovalbumin, poly(phosphoesters), poly(lactides), poly(glycolides), poly(caprolactones), poly(amides), poly(urethanes), poly(esteramides), poly(orthoesters), poly(dioxanones), poly(acetals), poly(ketals), poly(carbonates), poly(orthocarbonates), poly(phosphazenes), poly(hydroxybutyrates), poly(hydroxyl valerates), poly(alkylene oxalates), poly(alkylene succinates), poly(malic acids), polyvinylalcoholpoly(hydroxycellulose), chitin, chitosan, and copolymers, terpolymers or combinations or mixtures thereof.
地址 Baltimore MD US