| 摘要 |
Many pathogens, including Mycobacterium tuberculosis and Yersinia pestis, rely on an iron acquisition system based on siderophores, secreted iron-chelating compounds with extremely high Fe(III) affinity. The compounds of the invention are inhibitors of domain salicylation enzymes, which catalyze the salicylation of an aroyl carrier protein (ArCP) domain to form a salicyl-ArCP domain thioester intermediate via a two-step reaction. The compounds include the intermediate mimic 5′-O—[N-(salicyl)sulfamoyl]-adenosine (salicyl-AMS) and analogs thereof. These compounds are inhibitors of the salicylate activity of MbtA, YbtE, PchD, and other domain salicylation enzymes involved in the biosynthesis of siderophores. Therefore, these compounds may be used in the treatment of infection caused by microorganisms which rely on siderphore-based iron acquisition systems. Pharmaceutical composition and methods of using these compounds to treat or prevent infection are also provided as well as methods of preparing the inventive compounds. |
| 主权项 |
1. A compound of the formula:wherein:
X is O, S, —CH2—, NH, or N—Ac; A-B is —(RA)2C—C(RB)2—or —RAC═CRB—, wherein each occurrence of RA and RB is independently hydrogen, halogen, cyano, azido, hydroxyl, sulfhydryl, alkoxy, amino, alkylamino, dialkylamino, cyclic or acyclic, unsubstituted or substituted, branched or unbranched aliphatic, cyclic or acyclic, unsubstituted or substituted, branched or unbranched heteroaliphatic, substituted or unsubstituted, branched or unbranched acyl, substituted or unsubstituted, branched or unbranched aryl, substituted or unsubstituted, branched or unbranched heteroaryl; and L is substituted or unsubstituted, branched or unbranched acyl, or substituted or unsubstituted, branched or unbranched, cyclic or acyclic heteroaliphatic;or a pharmaceutically acceptable salt thereof. |
