发明名称 Peptide-based compounds and compositions which inhibit muscle contraction
摘要 Peptides of general formula (I): R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zs-R2 their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, their preparation process, cosmetic or pharmaceutical compositions which contain them and their use in the treatment and/or care of conditions, disorders and/or diseases that are a consequence of muscle contraction.
申请公布号 US8946166(B2) 申请公布日期 2015.02.03
申请号 US201013384557 申请日期 2010.07.23
申请人 Lipotec, S.A. 发明人 Garcia Sanz Nuria;Van Den Nest Wim;Carreno Serraima Cristina;Ferrer Montiel Antonio;Cebrian Puche Juan;Alminana Domenech Nuria;Fernandez Ballester Gregorio
分类号 A61K38/08;A61K38/03;A61K8/64;A61Q19/00;C07K7/06;C07K14/47;A61K38/00 主分类号 A61K38/08
代理机构 Fay Sharpe LLP 代理人 Fay Sharpe LLP
主权项 1. A peptide of general formula (I) R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zs-R2  (I) its stereoisomers, mixtures thereof and/or its cosmetic or pharmaceutically acceptable salts, wherein: AA1 is selected from the group consisting of -Asp-, -Glu- and -Pro-;AA2 is -Asp-;AA3 is selected from the group consisting of -Tyr- and -Arg-;AA4 is selected from the group consisting of -Phe- and -Tyr-;AA5 is selected from the group consisting of -Arg- and -Lys-;AA6 is selected from the group consisting of -Leu- and -Met-;W, X, Y and Z are independently selected from amongst themselves from the group consisting of coded amino acids and non-coded amino acids;n, m, p and s are independently selected from amongst themselves and have a value of between 0 and 1;R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic groups, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5—CO— wherein R5 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic groups, substituted or unsubstituted alicyclyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heterocyclyl, and substituted or unsubstituted heteroarylalkyl; andR2 is selected from the group consisting of —NR3R4, —OR3 and —SR3, wherein R3 and R4 are independently selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic groups, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted aralkyl.
地址 Gava-Barcelona ES