Treatment of tumors

摘要

The invention provides for innovative improvements in tumor therapy, particularly therapies which are conducted using endogenous substances and which have no or only mild side-effects. Accordingly the present invention relates to methods of treating or preventing tumor diseases other than lung cancer comprising administering a polypeptide with an angiotensin-converting-enzyme-2 (ACE2) activity.

主权项

1. A method of treating tumor diseases other than lung cancer comprising administering to a human patient in need thereof a recombinant, human, water-soluble, glycosylated with a sugar content greater than 10% by weight of total ACE2, dimeric angiotensin-converting-enzyme-2 (ACE2) polypeptide with ACE2 activity, wherein said recombinant, human, water-soluble, glycosylated with a sugar content greater than 10% by weight of total ACE2, dimeric ACE2 polypeptide comprises amino acids 18-740 of human wild type 805 amino acid ACE2, and wherein the tumor diseases are characterized by an increased angiotensin-II concentration in the tumor or in the tumor environment or in the tumor patient.