Screeningsfremgangsmåde, fremgangsmåde til oprensning af ikke-diffunderende a-beta oligomerer, selektive antistoffer mod nævnte ikke-diffunderingsdygtige a-beta oligomerer og en fremgangsmåde til fremstilling af nævnte antistoffer

摘要

Anti-Aglobulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies. The present invention relates to anti-Aglobulomer antibodies having a binding affinity to A(20-42) globulomer that is greater than the binding affinity of the antibody to A(1 -42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.