Diuretic testosterone derivs. - are 17-beta-hydroxy-17-alpha 3-hydroxypropyl-androsta-4,6,15-tri:ene-3-one derivs.

摘要

17 beta-Hydroxy-androst-4-ene-3-one derivs. of formula (I) are new: In the formula, R2 is H or an organic acid radical; R3 is methyl or ethyl; R4 is H or methyl; SCOR1; R1 is lower alkyl and (I) are aldosterone-type diuretics which invert the activity of deoxycorticosterone with respect to the excretion of sodium and potassium. In Hollmann tests they have superior activity to potassium canrenoate (I) are generally administered orally in doses of 20-500 mg/day.