| 摘要 |
The present invention provides substituted bicyclic heteroaryl compounds of formulae IIa, IIb, IIc, IId, IIe, IIf and IIg, including, for example, 4-pyrazolyl-N-arylpyrimidin-2-amines, 4-pyrazolyl-N-pyrazorylpyrimidin-2-amines and 4-pyrazolyl-N-pyridylpyrimidin-2-amines that modulate the activity of kinases and are useful in the treatment of diseases related to activity of kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases. |
