| 摘要 |
The invention relates to the pharmaceutical industry and to medicine, specifically to novel homo- and hetero-polyamino-acid derivatives of fullerene Cof general formula C(H){NH(CH)COO-}{NH(L)COOH)}, where n=2-5, x=3, L=-(CH), where m=1-5, or -CO(CH)CH(NH)-, where k=1-2, characterized in that the compounds comprise covalently bonded amino-acid groups and polar ionic forms of the amino acids, and also to a method for producing said derivatives, and to the production of pharmaceutical compositions based on same. The method for producing homo- and hetero-polyamino-acid derivatives of fullerene is based on the reaction of a nucleophilic bond of amino acids to fullerene, forming covalently bonded amino-acid derivatives of fullerene, with the subsequent introduction of polar ionic forms of the amino acids. A pharmaceutical composition comprises, as active substance, homo- and hetero-polyamino-acid derivatives of fullerene of formula C(H){NH(CH)COO-}{NH(L)COOH)}, where n=2-5, x=3, L=-(CH), where m=1-5, or - CO(CH)CH(NH)-, where k=1-2. |
