| 发明名称 |
SUBSTITUTED PYRIDINONES AS MODULATORS OF P38 MAP KINASE |
| 摘要 |
Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed. |
| 申请公布号 |
PL218749(B1) |
申请公布日期 |
2015.01.30 |
| 申请号 |
PL20030371943 |
申请日期 |
2003.02.14 |
| 申请人 |
PHARMACIA CORPORATION |
发明人 |
DEVADAS BALEKUDRU;WALKER JOHN;SELNESS SHAUN R.;BOEHM TERRI L.;DURLEY RICHARD C.;DEVRAJ RAJESH;HICKORY BRIAN S.;RUCKER PAUL V.;JEROME KEVIN D.;MADSEN HEATHER M.;ALVIRA EDGARDO;PROMO MICHELE A.;BLEVIS-BAL RADHIKA M.;MARRUFO LAURA D.;HITCHCOCK JEFF;OWEN THOMAS;NAING WIN;XING LI;SHIEH HUEY S.;SAMBANDAM ARUNA;LIU SHUANG;SCOTT IAN L.;MCGEE KEVIN F. |
| 分类号 |
C07D213/69;A61K31/4412;A61K31/4418;A61K31/4439;A61K31/444;A61K31/4545;A61K31/455;A61K31/4725;A61K31/496;A61K31/497;A61K31/506;A61K31/5377;A61P1/04;A61P1/16;A61P3/10;A61P7/02;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P15/08;A61P17/02;A61P17/06;A61P19/02;A61P19/06;A61P19/08;A61P19/10;A61P25/00;A61P25/02;A61P25/04;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P33/02;A61P33/06;A61P35/00;A61P37/06;A61P43/00;C07D213/64;C07D213/70;C07D213/74;C07D213/75;C07D213/79;C07D213/80;C07D213/82;C07D213/84;C07D213/85;C07D215/22;C07D401/04;C07D401/06;C07D401/10;C07D401/12;C07D401/14;C07D405/04;C07D405/06;C07D405/10;C07D405/12;C07D405/14;C07D409/06;C07D409/14;C07D413/06;C07D413/10;C07D413/12 |
主分类号 |
C07D213/69 |
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