发明名称 |
NOVEL POLYMORPHIC CRYSTAL FORMS OF 5-(2-{[6-(2,2-DIFLUORO-2-PHENYLETHOXY)HEXYL]AMINO}-1-(R)-HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE, HEMINAPADISYLATE AS AGONIST OF THE ß2 ADRENERGIC RECEPTOR. |
摘要 |
The present invention is directed to novel polymorphic crystal forms of a 5-{2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, heminapadisylate. The invention is also directed to pharmaceutical compositions comprising said polymorphic crystal forms, methods of using them to treat respiratory diseases associated with ²2 adrenergic receptor activity and a process for preparing such polymophic crystal forms. |
申请公布号 |
EP2828242(A1) |
申请公布日期 |
2015.01.28 |
申请号 |
EP20130719407 |
申请日期 |
2013.03.15 |
申请人 |
ALMIRALL S.A. |
发明人 |
AMAT MESTRES, GEMMA;BALAGUER ARDANUY, ELVIRA;CARRERA CARRERA, FRANCESC;MARCHUETA HEREU, IOLANDA;MOYES VALLS, ENRIQUE |
分类号 |
C07D215/26;A61K31/4704;A61P11/00 |
主分类号 |
C07D215/26 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|