发明名称 |
Pegylated interleukin-10 |
摘要 |
Interleukin-10 (IL-10) conjugated via a linker to one or more polyethylene glycol (PEG) molecules at a single amino acid residue of the IL-10, and a method for preparing the same, are provided. The method produces a stable mono-pegylated IL-10, which retains IL-10 activity, where pegylation is selective for the N-terminus on one subunit of IL-10 with little or no formation of monomeric IL-10. The method also provides a substantially homogenous population of mono-PEG-IL-10. |
申请公布号 |
EP2295450(B1) |
申请公布日期 |
2015.01.28 |
申请号 |
EP20100013313 |
申请日期 |
2001.09.28 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
LEE, SEOJU;WYLIE, DAVID C.;CANNON-CARLSON, SUSAN V. |
分类号 |
C07K14/54;A61K47/48;A61P29/00 |
主分类号 |
C07K14/54 |
代理机构 |
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地址 |
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