Mirabegron eller salter derav - (R)-2-(2-aminotiazol-4-yl)-4'-[2-[(2-hydroksy-2-fenyletyl)amino]etyl]eddiksyreanilid eller aminotiazolacetamide (2-(2-Amino-1,3-tiazol-4-yl)-N-[4-(2-[(2R)-2-hydroksy-2 fenyletyl]aminoetyl)fenyl]acetamid) - se krav 1 i patentet

摘要

(R)-2-(2-aminothiazol-4-yl)-4'-Ä2-Ä(2-hydroxy-2-phenylethyl)aminoÜethylÜacetic acid anilide or its salt shows a potent bladder relaxation effect in "isolated rat bladder smooth muscle relaxation test", dose-dependently lowers the contraction frequency of rhythmic bladder contractions in "rat rhythmic bladder contraction measurement test" and, moreover, prolongs the urination intervals in "urination functions measurement test on cyclophosphamide-induced overactive bladder model rat". Owing to these effects, the above compound is useful as a remedy for ovaractive bladder.