Reprogramming of Aged Adult Stem Cells

摘要

A method of reprogramming aged human or animal adult stem cells (AASC), comprising the steps of (a) collecting young adult stem cells (YASC) from the blood of a donor wherein the donor is less than 40 years old; (b) dissolving at least a portion of membranes of said YASC to release an intracellular matrix (ICM) thereof; (c) applying a supernatant of said ICM to a culture of AASC; and (d) following exposure of said AASC to said supernatant for a bioactively sufficient period, infusing such an exposed AASC to the donor thereof. A method comprising the steps of (a) collecting young adult stem cells (YASC) from the blood of a donor wherein the donor is less than 40 years old; (b) dissolving at least a portion of membranes of said YASC to release an intracellular matrix (ICM) thereof; (c) applying a supernatant of said ICM to a culture of aged adult stem cells (AASC) to produce exposed AASC; (d) recovering at least a portion of the exposed AASC; and (e) introducing the exposed AASC to the donor wherein the donor is greater than 40 years of age and is diagnosed with a disorder selected from the group consisting of AIDS, an age-related disease, and an immune deficiency disorder.

主权项

1. A method of reprogramming aged human or animal adult stem cells (AASC), comprising the steps of:
(a) collecting young adult stem cells (YASC) from the blood of a donor wherein the donor is less than 40 years old; (b) dissolving at least a portion of membranes of said YASC to release an intracellular matrix (ICM) thereof; (c) applying a supernatant of said ICM to a culture of AASC; and (d) following exposure of said AASC to said supernatant for a bioactively sufficient period, infusing such an exposed AASC to the donor thereof.