| 主权项 |
1. A composition comprising a Non-Sealed, radioactive pharmaceutically-acceptable composition of the formula
QqTt-Aa-Bb-Cc-Rr Formula (I) wherein:
Q is a Substrate of a different material from Aa-Bb-Cc entity, wherein such Substrate has the Aa-Bb-Cc entity deposited or adhered thereto; and is an injectable or implantable Substrate that is either pharmaceutically-acceptable or can be Coated to be pharmaceutically-acceptable;q is equal to 1 or 0, wherein 1 means the entity is present and 0 means the entity is not present;T is a non-radioactive iron hydroxide, iron oxide, gadolinium hydroxide or gadolinium oxide;t is equal to 1 or 0, wherein 1 means the entity is present and 0 means the entity is not present;A is JvM*w(OH)x(CO3)y(AN)z.nH2O, wherein:
J is a lanthanide metal ion capable of forming hydroxy carbonate compounds;v is greater than or equal to 0:M* is radioactive Sm-153, Ho-166, Y-90, or Lu-177 or mixtures thereof, wherein their respective non-radioactive Rare-earth Type Metal is usually present;w, x and y are each independently greater than 0;AN is a pharmaceutically-acceptable anionic moiety; andz and n are each independently greater than or equal to 0;a is equal to 1 or 0, wherein 1 means the entity is present and 0 means the entity is not present;B is M*w(OH)x(CO3)y.nH2O, wherein:
M* is radioactive Sm-153, 110-166, Y-90, or Lu-177 or mixtures thereof, wherein their respective non-radioactive Rare-earth Type Metal is usually present;w, x and y are each independently greater than 0; andn is greater than or equal to 0;b is equal to 1 or 0, wherein 1 means the entity is present and 0 means the entity is not present;C is Sn(L)u-{Mw(OH)x(CO3)y.nH2O}p, wherein:
Sn is radioactive tin (IV)-117m but also contains non-radioactive tin isotopes;L is hydrous oxide, hydroxide, or oxyhydroxide such that Sn(L)u is hydrous stannic oxide, stannic hydroxide, or stannic oxyhydroxide, or mixtures thereof;u is greater than 0;M is a Rare-earth Type Metal, or mixture thereof, wherein M can further include a radioactive Rare-earth Type Metal selected from the group consisting of Y-90, Sm-153, Ho-166, or Lu-177, or mixtures thereof;w, x and y are each independently greater than 0;n is greater than or equal to 0; andp is equal to 1 or 0, wherein 1 means the entity is present and 0 means the entity is not present;c is equal to 1 or 0, wherein 1 means the entity is present and 0 means the entity is not present;R is a Coat comprising a substance of a different composition than Aa-Bb-Cc entity, which covers A-Bb-Cc, and if q is 1, also Coats Substrate Q, and the resulting Coated composition is pharmaceutically-acceptable for injection; andr is equal to 1 or 0, wherein 1 means the entity is present and 0 means the entity is not present;with the provisos that one and only one of a, b and c are equal to 1, the others being equal to 0 (i.e. one and only one of A, B, or C is present); if either q or t is equal to 1, then the other is equal to 0 (i.e. only one of Q or T may optionally be present); each of u, v, w, x, y and z are of a numeric value, fractional values included, such that electrical neutrality is attained; and n is greater than or equal to 0 to provide optional water of hydration. |
