发明名称 ANTIBODIES TO BRADYKININ B1 RECEPTOR LIGANDS.
摘要 The disclosure provides antibodies that specifically bind to Kallidin or des-Arg10-Kallidin. The disclosure also provides pharmaceutical compositions, as well as nucleic acids encoding anti-Kallidin or des- Arg10-Kallidin antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies of the disclosure to modulate Kallidin or des-Arg10- Kallidin activity or detect Kallidin or des-Arg10-Kallidin or, either in vitro or in vivo, are also provided by the disclosure. The disclosure further provides methods of making antibodies that specifically bind to des-Argg- Bradykinin and des-Arg10-Kallidin-like peptide.
申请公布号 MX2014011688(A) 申请公布日期 2015.01.22
申请号 MX20140011688 申请日期 2013.03.15
申请人 SANOFI 发明人 XIN CHEN;NICOLAS BAURIN;HAN LI;DOROTHEA KOMINOS;JIE ZHANG;ALLA PRITSKER;MATTHEW DAVIDSON;GOVINDAN SUBRAMANIAN
分类号 C07K16/26;A61K39/395;A61P29/00;C07K7/18 主分类号 C07K16/26
代理机构 代理人
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