Human bispecific EGFRvIII antibody engaging molecules

摘要

We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging moleculess are highly cytotoxic and antigen-specific. These are promising therapeutic agents.