| 摘要 |
The present invention relates to a novel adenine derivative and a pharmaceutical use thereof and, more specifically, to a novel adenine derivative having a structure of chemical formula 1 or a pharmaceutically acceptable salt thereof and to a composition for preventing or treating degenerative brain disease, the composition containing the novel adenine derivative or the pharmaceutically acceptable salt thereof. The novel adenine derivative and the pharmaceutically acceptable salt thereof according to the present invention are adenosine A3 receptor agonists, and have an action of inhibiting the migration or infiltration of inflammatory cells (microglia, macrophages, neutrophils, etc.), to disease areas and the activities thereof. In addition, the adenine derivative according to the present invention was verified to suppress and treat brain injury more remarkably compared with the known adenosine A3 receptor agonists in a cerebral ischemia experimental model, exhibit significant effects by drug administration 10 hours after cerebral infarction, and allow long-term survival despite brain injury due to cerebral ischemia, and thus can be useful as an agent for treating and preventing degenerative brain disease including a stroke. |
